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Feb 18, 2022
Immune System
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As someone who takes charge of your health, you know the importance of exercising regularly, getting enough sleep every night, managing stress, and eating a nutritious, balanced diet. All this helps build a healthy immune system. Staying healthy year-round depends, in large part, on the proper functioning of your immune system. When it’s working correctly, you don’t even notice. But when your immune system stops working properly, you may take notice.
But exactly what is the immune system? And how does the immune system work?
If it’s been a few years since your high school biology class, you might want a quick refresher.
Keep reading to learn more about how the immune system works.
The immune system is your body’s way to defend against foreign substances called antigens that can cause infection, illness, and disease.[1] This complex and integrated system of cells, tissues, and organs work together, playing specialized roles in defending against these foreign substances or antigens.
Comprised of a large network of organs, cells, and proteins, the immune system has two main parts that work together:[3]
While you can see more detailed explanations of innate and adaptive immune systems below, they consist of these major parts:[1]
As the body's first line of defense, the innate immune system serves as a generalized rapid response system that you inherit at birth. The innate immune system contains “scavenger cells” called phagocytes, which quickly engulf and digest foreign substances as they enter the body.[3]
Because it responds similarly to all foreign substances entering the body, the innate system is sometimes called the “nonspecific” immune system. Although general in its approach, the innate system acts quickly, such as when foreign substances enter through broken skin and are quickly detected and destroyed. The body sends these killer scavenger cells (white blood cells called leukocytes) to defend. Though limited in its ability to stop the spread of in the body, the innate immune system protects via the skin and mucous membranes as well as the defense cells and proteins.[4]
The body’s second line of defense is the adaptive immune system (a.k.a. the acquired immune system). It takes a more targeted approach in its fight against foreign substances, and it changes throughout your life. After being exposed to a specific foreign substance invading the body, the adaptive system produces a specific antibody (developed by cells called B lymphocytes) to protect you. While it can take several days or weeks for these antibodies to develop, once the adaptive system has been exposed to a specific foreign body, it will recognize this specific invader in the future and defend against it.[3] For instance, when you receive an immunization, they train your adaptive immune system to make a specific antibody to protect you.
The adaptive immune system protects thanks to its components, including T lymphocytes (T cells) and B lymphocytes (B cells), which are both found in the tissue between the body's cells. Some of the T cells even have special names relevant to their function, such as helper T cells and killer T cells. The adaptive system also consists of antibodies, which are compounds of protein and sugar that circulate in the bloodstream, created to fight antigens (and other foreign substances). [4] This adaptive immunity (also called acquired immunity) takes over after the innate immunity reaches its limited ability to protect against pathogens.[2]
Now that you understand the innate and adaptive immune system (and you know the main body parts involved), you can better understand how the immune system works. The immune system helps fight invaders and its main tasks include:[5]
The body mobilizes an immune response to deal with foreign invaders. Sometimes, though, the body mounts an immune response against its own tissues instead of a foreign invader. When this occurs, it’s called an autoimmune disorder or an autoimmune disease.[2]
How does the immune system work? Your body’s amazing immune system protects you against foreign substances. It consists of both the innate immune system and the adaptive immune system, which work together to protect you. The primary immune system cells, tissues, and organs include white blood cells, lymph nodes, spleen, tonsils, adenoids, thymus, bone marrow, skin, mucous membranes, stomach, and bowel. The primary tasks of the immune system include fighting foreign substances.
Continue to check back on the Nature Made blog for the latest science-backed articles to help you take ownership of your health.
This information is for educational purposes only and is not intended to serve as medical advice or a recommendation for any specific product. Consult your health care provider for more information.
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