Can I Take Berberine Before Bed? Supplements Guide

Nature Made® is now offering a new Berberine Phytosome supplement. This clinically studied ingredient helps support healthy glucose and lipid metabolism and cardiovascular health in older adults on a calorie-restricted diet when taken twice a day for at least two months. Nature Made^® Berberine Phytosome Capsules have five times the bioavailability of standard Berberine Chloride.‡ You might want to know what Berberine is, and the answer to “can I take Berberine before bed?” so read on!^†

What is Berberine?

You may have heard of Berberine supplements if you're keeping up on supplement news. Despite this "news," the use of Berberine in traditional medicine is quite old! Berberine has been used in traditional Ayurvedic and Chinese medicine for thousands of years.[1] Berberine is a naturally occurring compound found in plants in the Berberis genus, most notably in the roots of Berberis aristata (AKA Indian Barberry). Nature Made^® Berberine Phytosome combines the ingredient Berberine with a phytosome matrix. A phytosome is a lipid container that incorporates the ingredient into its structure, allowing the body to dissolve and absorb the ingredient more effectively. Encasing Berberine extract in a phytosome has been shown to considerably increase the bioavailability and absorption of Berberine into the body.[2] This delivery mechanism helps us absorb Berberine, making it five times more bioavailable than standard Berberine.‡ Once it has been absorbed into the body, Berberine helps support cardiovascular health, along with supporting healthy glucose metabolism and lipid metabolism.*^†

Can I Take Berberine Before Bed?

The reason you're here, the answer to the question: can I take Berberine before bed? Here's some good news: yes! Taking Berberine before bed shouldn't impact sleep at all. Nature Made^® Berberine Phytosome is suggested to be taken twice daily; attaching it to your morning regimen and your bedtime routine to help stick to a consistent supplement schedule. If you're looking for sleep support, Nature Made^® Melatonin is a drug-free way to support your rest occasionally. Sometimes, exposure to the blue light of screens before bedtime can inhibit our body's production of Melatonin, a hormone naturally produced in our brain, so occasionally, taking a Melatonin supplement can help reset your body's natural sleep cycle. Try limiting your screen time at night, cutting out blue light exposure 30 minutes before bedtime.^†

Best Practices for Berberine Consumption

So, what are the best practices for Berberine consumption? Here are our suggestions! Take one capsule (550 mg of Berberine Phytosome) twice daily. We recommend taking each of your Berberine capsules before a separate meal; for example, in the clinical study of the effects of Berberine Phytosome, Berberine Phytosome was taken before lunch and then again before dinner.[3,4] But everyone’s needs and schedules are different, so choose what works best for you.

How Often Can I Take Berberine?

Is Berberine safe to take twice a day? It's safe to take Berberine capsules two times a day as long as you take them as directed. You can take your Berberine capsules once in the morning and once at night.

When is the Best Time to Take Berberine?

Is there a "best time" to take Berberine? If you're looking for an exact time on the clock, then no, but there are some tips you can follow to help support your Berberine supplementation. As stated above, we recommend taking Berberine twice daily as part of your regular routine. Taking your supplements alongside a pre-existing routine is generally a good idea for consistency, and if you decide to take our Berberine supplement, adding it to your pre-existing supplement routine makes it easy to remember. Taking Berberine in our Berberine Phytosome capsule form helps increase Berberine's bioavailability fivefold!‡ It's always necessary to consult with a healthcare provider before beginning a new supplement routine or making any changes or additions to a pre-existing routine.^†

Shop Nature Made^®'s New Berberine Supplement

Nature Made^® is proud to offer our new Berberine Phytosome Capsules with a clinically studied ingredient. Berberine Phytosome helps support healthy glucose and lipid metabolism, and they also support cardiovascular health!■ If you’re looking for a Berberine supplement with no artificial sweeteners, no artificial flavors and no added color, look no further! Our Berberine supplement is also gluten-free. Our supplements are made with high-quality ingredients; make an informed choice with Nature Made^®.^†

For other health benefits, check out Nature Made^®’s other supplements. Our Digestive Probiotics Ultra Strength◆ Gummies support healthy digestion. Check out our Vitamin D3 Softgels for bone, teeth, muscle and immune health support. For tips on how to improve heart health, including the best vitamins for heart health support, we’ve got blogs for you. Always consult your primary care provider or another healthcare professional before beginning or changing your supplement routine.^†

*In older adults on a calorie-restricted diet.

‡ Compared to berberine chloride when taken on empty stomach.

■ When taken twice a day for at least 2 months

♦2X the CFUs of other Nature Made® Digestive Probiotics Adult Gummies (4 billion CFUs).

† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

1. In the News: Berberine. NCCIH. Published June 2023. Accessed July 18, 2024. https://www.nccih.nih.gov/health/in-the-news-berberine
2. Petrangolini G, Corti F, Ronchi M, Arnoldi L, Allegrini P, Riva A. Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study. Evid Based Complement Alternat Med. 2021;2021:7563889. Published 2021 Nov 27. doi:10.1155/2021/7563889
3. Rondanelli M, Gasparri C, Petrangolini G, et al. Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. Eur Rev Med Pharmacol Sci. 2023;27(14):6718-6727. doi:10.26355/eurrev_202307_33142

4. Natural Medicines Comprehensive Database Consumer Version [Internet]. Stockton (CA): Therapeutic Research Faculty; c1995-2018. Berberine; [reviewed 2024 Feb 22; cited 2024 May 15]; Available from: https://medlineplus.gov/druginfo/natural/1126.html