3 Berberine Phytosome Benefits to Support a Healthy Body

What is Berberine? What is Berberine Phytosome? Those are some good questions! Unlike the well-known supplements, Vitamin D and Calcium (among countless others), Berberine is a relative newcomer on the dietary supplement scene, though that doesn't mean it's new to everyone! Berberine is a compound naturally occurring in several plants, like Philodendron, Oregon grape, and European barberry, and it has been used in Ayurvedic and traditional Chinese medicine for thousands of years.[1] Our new Berberine supplement includes a clinically studied Berberine Phytosome to help support healthy glucose and lipid metabolism.*^†

What is Berberine Phytosome?

Now we know what Berberine is, but what is Berberine Phytosome? A phytosome is a lipid-based nutrient delivery mechanism; the nutrient is encapsulated in a lipid (fat) layer that aids in the body's absorption.[2] So, a Berberine Phytosome is a form of Berberine in which the nutrient is encased inside a phytosome. Our specific Berberine Phytosome (BERBEVIS^® phytosome) is an ingredient based on the formulation of Berberine from the roots of Berberis aristata (AKA Indian Barberry) coupled with a phytosome matrix. Encasing the raw Berberine extract in a phytosome has been shown to significantly increase Berberine’s absorption when compared to the unformulated extract.[3]. Nature Made^® Berberine Phytosome has five times higher bioavailability than standard Berberine Hydrochloride (Berberine HCl) also known as Berberine Chloride.‡^†

3 Berberine Phytosome Benefits

So, what are some Berberine Phytosome benefits? Berberine has been used in traditional Ayurvedic and Chinese medicine for thousands of years. Our Berberine supplement includes clinically studied Berberine to support several health benefits, like the following:^†

Enhanced Bioavailability

Nature Made^® Berberine Phytosome has five times higher bioavailability than standard Berberine extracts.‡ Combining Berberine with a phytosome matrix (remember, a fat container) makes the resulting molecule more soluble than Berberine extract alone, allowing it to dissolve and absorb into your body more efficiently.^†

Supports Cardiovascular Health

If you want to support your cardiovascular health, read on! Nature Made^® Berberine Phytosome helps support cardiovascular health in older adults on a calorie-restricted diet.^†

Supports Healthy Glucose and Lipid Metabolism

Berberine Phytosome also supports healthy blood sugar metabolism and lipid metabolism.* We get glucose (sugar) from the food we eat, which our body then uses as fuel in the metabolic process, which produces cellular energy.[4] In a clinical trial where older adults on a calorie-restricted diet were administered Berberine, a statistically significant difference was observed on day 60 between those supplemented with Berberine Phytosome and the placebo group for blood sugar, total cholesterol, and triglycerides.[5] Nature Made^® Berberine Phytosome is a better absorption‡ Berberine capsule that supports healthy lipid metabolism and cardiovascular health*.^†

How to Incorporate a Berberine Supplement into Your Diet

The easiest way to incorporate two daily Berberine capsules into your diet is by attaching them to a pre-existing routine. Remembering to take Berberine alone can be difficult, but by attaching it to something you do twice daily (like brushing your teeth, washing your face, etc.), you are much more likely to remember to take your Berberine capsules regularly.

Nature Made^®'s New Berberine Supplement

Nature Made^® is happy to provide a source of Berberine Phytosome benefits! First, the clinically studied ingredient helps support healthy glucose and lipid metabolism and cardiovascular health.*■ This Berberine supplementation has no artificial sweeteners, no artificial flavors, and no added color. All of our supplements are held to Nature Made^®’s high-quality standards. Those with a gluten-restricted diet may also be happy to learn that Nature Made^® Berberine Phytosome is gluten-free! Make an informed choice; Nature Made^® is dedicated to providing safe supplements with high-quality ingredients.^†

Empower Your Health Journey Today!

Everyone's health journey is unique, just like everyone's needs are different. Taking steps towards a healthier lifestyle is something to be proud of, and every little bit helps. Eating a nutritious diet, taking care of your body, and ensuring you get support are all critical to your health. If you are looking for a way to support healthy glucose and lipid metabolism, along with cardiovascular health, Nature Made^® offers you clinically studied support.*■ With five times higher bioavailability than Berberine Hydrochloride (when taken on an empty stomach), see the Berberine Phytosome benefits for yourself with Nature Made^® Berberine Phytosome Capsules. Can I take Berberine before bed? That’s a question for another blog.^†

Check out Nature Made^®’s other nutritional support supplements! Our Digestive Probiotics Advanced Dual Action Capsules provide two clinically studied strains of probiotics to support a healthy gut microbiome. For healthy skin, hair and nail support, check out Biotin Extra Strength Softgels. For tips on how to improve heart health, including the best vitamins for heart health support, we’ve got blogs for you. Always consult your primary care provider or another healthcare professional before starting a vitamin or supplement routine, changing your supplement routine, or if you have any health concerns.^†

* In older adults on a calorie-restricted diet.

‡ Compared to Berberine hydrochloride (HCl) when taken on an empty stomach.

■ When taken twice a day for at least 2 months

† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

1. In the News: Berberine. NCCIH. Published June 2023. Accessed July 18, 2024. https://www.nccih.nih.gov/health/in-the-news-berberine
2. Ghanbarzadeh et al. Phytosome - an overview | ScienceDirect Topics. www.sciencedirect.com. Published 2016. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/phytosome
3. Petrangolini G, Corti F, Ronchi M, Arnoldi L, Allegrini P, Riva A. Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study. Evid Based Complement Alternat Med. 2021;2021:7563889. Published 2021 Nov 27. doi:10.1155/2021/7563889
4. Chaudhry R, Varacallo M. Biochemistry, Glycolysis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482303/
5. Rondanelli M, Gasparri C, Petrangolini G, et al. Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. Eur Rev Med Pharmacol Sci. 2023;27(14):6718-6727. doi:10.26355/eurrev_202307_33142